Alaska's senior U.S. senator says the structural problem within the U.S. Department of Veterans Affairs is "far larger than one man."

Republican Sen. Lisa Murkowski was reacting to the resignation of VA Secretary Eric Shinseki on Friday.

She said in a statement that if true reform is to be enacted and felt within the VA, "Shinseki should be the first of many, many more to depart the agency."

The resignation comes amid allegations of problems, including delayed medical care, at VA facilities across the country.

Both Murkowski and Democratic Sen. Mark Begich had reserved judgment on Shinseki and had not called for his resignation.