PHILADELPHIA -- A.J. Burnett pitched 7 1/3 strong innings and Marlon Byrd drove in four runs Tuesday as the Philadelphia Phillies beat the San Diego Padres 5-2.

Byrd, the right fielder, hit a three-run homer in the fourth inning to snap a 1-1 tie. He also drove in a run with a sacrifice fly in the sixth, as the Phillies won for just the second time in 10 games.

Center fielder Will Venable hit a solo homer for San Diego, which lost for the sixth time in eight games.

Facing a Padres team that began the night hitting a major league-worst .218, Burnett (4-5) allowed two runs and five hits while striking out three and walking two. He ended a two-game losing streak, and a six-start stretch in which he went 1-4 with a 7.25 ERA.

Burnett's three strikeouts left him with 2,250 for his career, one behind Eddie Plank, who is 50th on the all-time list.

Jake Diekman struck out two batters to end the eighth. Jonathan Papelbon allowed two hits and hit a batter to load the bases in the ninth, but retired pinch hitter Tommy Medica to end the game and earn his 14th save. It was also the 300th save of Papelbon's career.

San Diego starter Ian Kennedy (5-7) saw a three-game winning streak end, allowing five runs on seven hits over seven innings of work. He struck out three and did not walk a batter.

Venable's homer, his second of the year, came with two outs in the third and gave San Diego a 1-0 lead.

The Phillies were unable to produce a baserunner against Kennedy until center fielder Ben Revere led off the fourth with a double. One out later, second baseman Chase Utley singled home Revere.

First baseman Ryan Howard followed with a single, and Byrd then hit a 3-2 fastball from Kennedy into the seats in right center field for his 10th homer of the season, giving Philadelphia a 4-1 lead.

NOTES: Phillies manager Ryne Sandberg said before the game that LHP Cliff Lee, on the disabled list since May 21 with a sore pitching elbow, is making progressing and getting closer to picking up a ball. ... Sandberg also said 3B Cody Asche, out since May 25 with a strained hamstring, is playing in simulated games in extended spring training and will continue to do so until Thursday. Asche will begin a rehab assignment Friday. ... Philadelphia RHP Mike Adams, placed on the disabled list Sunday, underwent an MRI that revealed fraying of the labrum in his pitching shoulder but no rotator cuff damage. He will receive a cortisone shot later this week, meaning he will not be able to throw for at least 10 days. ... The Phillies announced the signing of first-round draft pick Aaron Nola, a right-hander from LSU. GM Ruben Amaro Jr. said Nola likely would start at Class A Clearwater. ... The Padres outrighted LHP Jason Lane to Triple-A El Paso.