PRP is short for "platelet rich plasma." Howard will first have some of his own blood removed and spun in a centrifuge.
The resulting plasma, which contains a high dose of Howard's own platelets to promote healing, will be injected into his shoulder.
Howard will miss the Lakers' visit to the Minnesota Timberwolves but will fly out to rejoin the team in Detroit.
There's a short recovery time after the nonsurgical PRP procedure. It's unclear if Howard will be ready to play against the Pistons on Sunday.
The Lakers have lost eight straight road games and will play their next six away from Staples Center.