ANCHORAGE (KTUU) — Update: 4:40 p.m.:
The Parks Highway has been reopened as of 4:30 p.m.
Update: 2:27 p.m.:
One person has died following the head-on collision near Mile Post 89 of the Parks Highway according to Alaska State Troopers.
The number and extent of others who suffered injury is currently unknown.
Alaska State Troopers spokesman Tim DeSpain says the Parks Highway is still closed in both directions.
DeSpain says the vehicles involved were a 2016 Toyota Camry that struck a 2002 Chevy pickup truck.
Three people were taken to the hospital with what are believed to be non-life threatening injuries.
The Parks Highway was expected to be reopened by about 3:10 p.m.
Another large crash shut down a major Alaska highway on Friday, after two cars reportedly collided head-on near Willow.
According to Alaska State Troopers, the crash was reported near Mile Post 89 of the Parks Highway.
Tim Despain, spokesperson with AST, said that two vehicles crashed directly into one another, and there were reports of injuries.
At least one person was seriously injured, and transported in a Life-Med helicopter. Other details, such as any deaths, number of people injured, and types of vehicles, is still being determined.
Despain said troopers, BHP, State Park Rangers and EMS responded to the call, which came in just after 11 a.m. on Friday.
The Department of Transportation issued an alert saying the road will be closed for a number of hours while emergency vehicles remain on the roadway, and clearing takes place. "Be prepared to stop," the DOT wrote.
Also Friday, a crash south of Anchorage on the Seward Highway killed one person when a truck and an SUV collided.
This is a developing story and will be updated.